May Dove Canady (Angela Bettis) is an awkward, lonely young woman, who suffered from a rough childhood due to her lazy eye. She has very few social interactions, her only “true friend” being a glass-encased doll named Suzie made by her mother and given to May for her birthday with the adage “If you can’t find a friend, make one.” May works at a veterinary hospital, assisting with surgeries. Her optometrist fixes May’s lazy eye, first with glasses, then with contact lens. May becomes friends with Adam (Jeremy Sisto), a local mechanic. She has a fixation on his hands, which she considers to be the most attractive part of him, and they start dating. May’s lesbian colleague Polly (Anna Faris) begins to flirt with May. One day, May remarks that Polly has a beautiful neck. They become friends and Polly gives her pet cat Lupe to May.
May invites Adam to her apartment and he shows her a film he made for his university titled Jack and Jill. The film reveals a story of two young lovers who go on a picnic and end up eating each other. May becomes aroused by the cannibalism in the film. During an intense make-out session, she bites Adam on the lip and it bleeds. Disturbed by her strange behavior, Adam abruptly leaves sending May on a weird scary psychological journey!