Rise of the Machine Girls – long gone are the days of freedom. Preying on the weak and defenceless, the Dharma Family rules the town. It is now a time devoid of justice and order.
Abandoned by their mother at a young age, Ami and her sister Yoshie scrape by doing fight shows for the Gotai Troupe. One night, while Ami is at night school, Yoshie carries out a surprise attack on the black market organ organization run by the evil Dharma Family. Unexpectedly, Yoshie is met by the Battle Bust Sisters – female killing machines designed by Dharma Aoyama – and is captured. Hearing of this, Ami rushes to her sister’s rescue. Outmatched, Ami has an arm ruthlessly severed off by Dharma Aoyama before being dumped unconscious in the street.
Hours later, Ami awakes more determined than ever to get her sister back. Defying excruciating pain, she attaches a machine gun to the stump of her left arm and charges into the enemy’s lair only to find that she is too late: Yoshie has been transformed into a human cyborg programmed to kill her! Worse still, Dharma Aoyama has enlisted the talents of Kikyo, the deadliest of assassins. As they face off, the battle escalates into out-and-out war! Will Ami find a way to bring her sister back?