Tromaville’s nuclear reactor has been rebuilt since the events of Class of Nuke ‘Em High (1986) and it was funded by the Nukamama Corporation and created a new college – the Tromaville Institute of Technology (T.I.T.), which is located inside the nuclear plant.

At T.I.T. Professor Holt has perfected a race of ‘Sub-humanoids’; living beings without emotions, who have been created and programmed to perform menial tasks.

Soon school reporter Roger Smith meets a beautiful subhumanoid named Victoria, they fall in love… what could go wrong?